Publication Date
2-1-2024
Journal
Influenza and Other Respiratory Viruses
DOI
10.1111/irv.13250
PMID
38314065
PMCID
PMC10831571
PubMedCentral® Posted Date
2-1-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Infant, Humans, Cohort Studies, Viruses, Enterovirus Infections, Enterovirus, Respiratory Syncytial Virus, Human, Antigens, Viral, Fever, Picornaviridae Infections, enterovirus, febrile infants, parechovirus, respiratory viral infections, serious bacterial infections
Abstract
BACKGROUND: Respiratory viral infections are common in febrile infants ≤90 days. However, the detection of viruses other than enterovirus in the blood and cerebrospinal fluid (CSF) of young infants is not well defined. We sought to quantify the occurrence of respiratory viruses in the blood and CSF of febrile infants ≤90 days.
METHODS: We conducted a nested cohort study examining plasma and CSF samples from febrile infants 15-90 days via rtPCR. The samples were tested for respiratory viruses (respiratory syncytial virus, influenza, enterovirus, parechovirus, adenovirus, bocavirus). Clinical and laboratory data were also collected to determine the presence of serious bacterial infections (SBI).
RESULTS: Twenty-four percent (30 of 126) of infants had plasma/CSF specimens positive for a respiratory virus. Enterovirus and parechovirus were the most commonly detected respiratory viruses. Viral positivity was highest in plasma samples at 25% (27 of 107) compared with CSF samples at 15% (nine of 62). SBIs (specifically urinary tract infections) were less common in infants with a sample positive for a respiratory virus compared to those without a virus detected (3% vs. 26%,
CONCLUSIONS: Our findings support the use of molecular diagnostics to include the identification of parechovirus in addition to enterovirus in febrile infants ≤90 days. Additionally, these data support the utilization of blood specimens to diagnose enterovirus and parechovirus infections in febrile infants ≤90 days.
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