Publication Date
1-27-2022
Journal
Annual Review of Medicine
DOI
10.1146/annurev-med-042320-023055
PMID
34644153
PMCID
PMC8887824
PubMedCentral® Posted Date
3-1-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Communicable Diseases, Humans, Organoids, organoid, infection, stem cell, pathogenesis, therapies
Abstract
Infectious diseases affect individual health and have widespread societal impacts. New ex vivo models are critical to understand pathogenesis, host response, and features necessary to develop preventive and therapeutic treatments. Pluripotent and tissue stem cell-derived organoids provide new tools for the study of human infections. Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions. Increasing culture complexity by adding the stroma, interorgan communication, and the microbiome will improve the use of organoids as models for infection. Organoid cultures provide a platform with the capability to improve human health related to infectious diseases.