The RSV F p27 Peptide: Current Knowledge, Important Questions

Authors

Wanderson Rezende
Hadley E Neal
Rebecca E Dutch
Pedro A Piedra

Publication Date

1-1-2023

Journal

Frontiers in Microbiology

DOI

10.3389/fmicb.2023.1219846

PMID

37415824

PMCID

PMC10320223

PubMedCentral® Posted Date

6-21-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

respiratory syncytial virus (RSV), p27, fusion protein (F), cleavage, F protein trimer

Abstract

Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.