Publication Date
9-15-2023
Journal
iScience
DOI
10.1016/j.isci.2023.107596
PMID
37664586
PMCID
PMC10470378
PubMedCentral® Posted Date
8-9-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Cell biology, Immunology, Microbiology, Stem cells research, Transcriptomics
Abstract
Recent studies suggest that infection reprograms hematopoietic stem and progenitor cells (HSPCs) to enhance innate immune responses upon secondary infectious challenge, a process called "trained immunity." However, the specificity and cell types responsible for this response remain poorly defined. We established a model of trained immunity in mice in response to
Graphical Abstract
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