Language

English

Publication Date

1-1-2023

Journal

International Journal of Biological Sciences

DOI

10.7150/ijbs.81609

PMID

36778129

PMCID

PMC9910000

PubMedCentral® Posted Date

1-16-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Mitochondria are intracellular organelles involved in energy production, cell metabolism and cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism and nucleic acid metabolism, but also in tumor development and metastasis. Mutations in mtDNA are commonly found in cancer cells to promote the rewiring of bioenergetics and biosynthesis, various metabolites especially oncometabolites in mitochondria regulate tumor metabolism and progression. And mutation of enzymes in the TCA cycle leads to the unusual accumulation of certain metabolites and oncometabolites. Mitochondria have been demonstrated as the target for cancer treatment. Cancer cells rely on two main energy resources: oxidative phosphorylation (OXPHOS) and glycolysis. By manipulating OXPHOS genes or adjusting the metabolites production in mitochondria, tumor growth can be restrained. For example, enhanced complex I activity increases NAD+/NADH to prevent metastasis and progression of cancers. In this review, we discussed mitochondrial function in cancer cell metabolism and specially explored the unique role of mitochondria in cancer stem cells and the tumor microenvironment. Targeting the OXPHOS pathway and mitochondria-related metabolism emerging as a potential therapeutic strategy for various cancers.

Keywords

Humans, Neoplasms, Mitochondria, Energy Metabolism, Citric Acid Cycle, Oxidative Phosphorylation, Tumor Microenvironment, mitochondria, cancer, tumor metastasis, tumor metabolism

Published Open-Access

yes

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