Hyaluronan Mediates Cold-Induced Adipose Tissue Beiging

Authors

Xi Chen
Yifan Wang
Huiqiao Li
Yanru Deng
Charlise Giang
Anying Song
Yu'e Liu
Qiong A Wang
Yi Zhu

Publication Date

7-23-2024

Journal

Cells

DOI

10.3390/cells13151233

PMID

39120264

PMCID

PMC11311271

PubMedCentral® Posted Date

7-23-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Hyaluronic Acid, Animals, Cold Temperature, Mice, Adipose Tissue, White, Mice, Inbred C57BL, Male, Adipose Tissue, Beige, Adipocytes, Beige, Extracellular Matrix, Dioxoles, Receptors, Adrenergic, beta-3, Adrenergic beta-3 Receptor Agonists, hyaluronan, cold-induced adipose tissue beiging, extracellular matrix, HAS2, PH20

Abstract

Adipose tissue beiging refers to the process by which beige adipocytes emerge in classical white adipose tissue depots. Beige adipocytes dissipate chemical energy and secrete adipokines, such as classical brown adipocytes, to improve systemic metabolism, which is beneficial for people with obesity and metabolic diseases. Cold exposure and β3-adrenergic receptor (AR) agonist treatment are two commonly used stimuli for increasing beige adipocytes in mice; however, their underlying biological processes are different. Transcriptional analysis of inguinal white adipose tissue (iWAT) has revealed that changes in extracellular matrix (ECM) pathway genes are specific to cold exposure. Hyaluronic acid (HA), a non-sulfated linear polysaccharide produced by nearly all cells, is one of the most common components of ECM. We found that cold exposure significantly increased iWAT HA levels, whereas the β3-AR agonist CL316,243 did not. Increasing HA levels in iWAT by

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