Publication Date
9-1-2023
Journal
Trends in Endocrinology & Metabolism
DOI
10.1016/j.tem.2023.06.005
PMID
37468429
PMCID
PMC10529122
PubMedCentral® Posted Date
9-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Humans, Female, Pregnancy, Folic Acid, Neural Tube, Neurulation, Placenta, Neural Tube Defects, Yolk sac, neural tube, glucose, folate, maternal-fetal communication
Abstract
Changes in maternal nutrient availability due to diet or disease significantly increase the risk of neural tube defects (NTDs). Because the incidence of metabolic disease continues to rise, it is urgent that we better understand how altered maternal nutrient levels can influence embryonic neural tube development. Furthermore, primary neurulation occurs before placental function during a period of histiotrophic nutrient exchange. In this review we detail how maternal metabolites are transported by the yolk sac to the developing embryo. We discuss recent advances in understanding how altered maternal levels of essential nutrients disrupt development of the neuroepithelium, and identify points of intersection between metabolic pathways that are crucial for NTD prevention.
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Life Sciences Commons, Maternal and Child Health Commons, Medical Cell Biology Commons, Medical Microbiology Commons, Medical Molecular Biology Commons, Medical Specialties Commons, Women's Health Commons