Publication Date
3-5-2024
Journal
Proceedings of the National Academy of Sciences
DOI
10.1073/pnas.2320559121
PMID
38408237
PMCID
PMC10927585
PubMedCentral® Posted Date
2-26-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Animals, Mice, Adaptor Proteins, Signal Transducing, Carcinoma, Squamous Cell, Cell Cycle Proteins, Homeostasis, Signal Transduction, Stem Cells, Tumor Suppressor Protein p53, YAP-Signaling Proteins, basal progenitor cells, epithelial homeostasis, foregut squamous cell carcinoma, Hippo, p53
Abstract
Basal progenitor cells serve as a stem cell pool to maintain the homeostasis of the epithelium of the foregut, including the esophagus and the forestomach. Aberrant genetic regulation in these cells can lead to carcinogenesis, such as squamous cell carcinoma (SCC). However, the underlying molecular mechanisms regulating the function of basal progenitor cells remain largely unknown. Here, we use mouse models to reveal that Hippo signaling is required for maintaining the homeostasis of the foregut epithelium and cooperates with p53 to repress the initiation of foregut SCC. Deletion of
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Life Sciences Commons, Medical Cell Biology Commons, Medical Microbiology Commons, Medical Molecular Biology Commons, Medical Specialties Commons, Neoplasms Commons
Comments
Associated Data