The NR2F2-HAND2 Signaling Axis Regulates Progesterone Actions in the Uterus at Early Pregnancy

Authors

Yeongseok Oh
Elvis Quiroz
Tianyuan Wang
Yassmin Medina-Laver
Skylar Montague Redecke
Francisco Dominguez
John P Lydon
Francesco J DeMayo
San-Pin Wu

Publication Date

1-1-2023

Journal

Frontiers in Endocrinology

DOI

10.3389/fendo.2023.1229033

PMID

37664846

PMCID

PMC10473531

PubMedCentral® Posted Date

8-18-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Female, Humans, Pregnancy, Animals, Mice, Progesterone, Uterus, Signal Transduction, Endometrium, Orphan Nuclear Receptors, COUP Transcription Factor II

Abstract

Endometrial function is dependent on a tight crosstalk between the epithelial and stromal cells of the endometrium. This communication is critical to ensure a fertile uterus and relies on progesterone and estrogen signaling to prepare a receptive uterus for embryo implantation in early pregnancy. One of the key mediators of this crosstalk is the orphan nuclear receptor NR2F2, which regulates uterine epithelial receptivity and stromal cell differentiation. In order to determine the molecular mechanism regulated by NR2F2, RNAseq analysis was conducted on the uterus of

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