Language

English

Publication Date

11-15-2023

Journal

Neuron

DOI

10.1016/j.neuron.2023.08.010

PMID

37683629

Abstract

Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive impairment and neurodegeneration. It is unclear what drives BBB leakage in aging and how it can be prevented. Using single-nucleus transcriptomics, we identified decreased connexin 43 (CX43) expression in cadherin-5

Keywords

Animals, Humans, Mice, Aging, Blood-Brain Barrier, Brain, Connexin 43, NAD, Poly (ADP-Ribose) Polymerase-1

Published Open-Access

yes

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