Triobp Modulates β-Catenin Signaling by Regulation of miR-29b in Idiopathic Pulmonary Fibrosis

Authors

• Lan Wang
• Wenyu Zhao
• Cong Xia
• Shuaichen Ma
• Zhongzheng Li
• Ningdan Wang
• Linke Ding
• Yaxuan Wang
• Lianhui Cheng
• Huibing Liu
• Juntang Yang
• Yajun Li
• Ivan Rosas
• Guoying Yu

Language

English

Publication Date

12-29-2023

Journal

Cellular and Molecular Life Sciences

DOI

10.1007/s00018-023-05080-4

PMID

38157020

PMCID

PMC10756874

PubMedCentral® Posted Date

12-29-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal and devastating lung disease of unknown etiology, described as the result of multiple cycles of epithelial cell injury and fibroblast activation. Despite this impressive increase in understanding, a therapy that reverses this form of fibrosis remains elusive. In our previous study, we found that miR-29b has a therapeutic effect on pulmonary fibrosis. However, its anti-fibrotic mechanism is not yet clear. Recently, our study identified that F-Actin Binding Protein (TRIOBP) is one of the target genes of miR-29b and found that deficiency of TRIOBP increases resistance to lung fibrosis in vivo. TRIOBP knockdown inhibited the proliferation of epithelial cells and attenuated the activation of fibroblasts. In addition, deficiency of Trio Rho Guanine Nucleotide Exchange Factor (TRIO) in epithelial cells and fibroblasts decreases susceptibility to lung fibrosis. TRIOBP interacting with TRIO promoted abnormal epithelial-mesenchymal crosstalk and modulated the nucleocytoplasmic translocation of β-catenin. We concluded that the miR-29b‒TRIOBP-TRIO-β-catenin axis might be a key anti-fibrotic axis in IPF to regulate lung regeneration and fibrosis, which may provide a promising treatment strategy for lung fibrosis.

Keywords

Animals, Humans, Mice, beta Catenin, Fibroblasts, Fibrosis, Idiopathic Pulmonary Fibrosis, Lung, Mice, Inbred C57BL, Microfilament Proteins, MicroRNAs, Signal Transduction

Published Open-Access

yes

Recommended Citation

Wang, Lan; Zhao, Wenyu; Xia, Cong; et al., "Triobp Modulates β-Catenin Signaling by Regulation of miR-29b in Idiopathic Pulmonary Fibrosis" (2023). Faculty, Staff and Students Publications. 2042.
https://digitalcommons.library.tmc.edu/baylor_docs/2042