Publication Date
1-1-2023
Journal
American Journal of Clinical and Experimental Urology
PMID
38148936
PMCID
PMC10749386
PubMedCentral® Posted Date
12-15-2023
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Prostate cancer, tumor metabolism, adenosine deaminase, cell adhesion, tumor progression
Abstract
Prostate cancer (PCa) is the second most common cancer and constitutes about 14.7% of total cancer cases. PCa is highly prevalent and more aggressive in African-American (AA) men than in European-American (EA) men. PCa tends to be highly heterogeneous, and its complex biology is not fully understood. We use metabolomics to better understand the mechanisms behind PCa progression and disparities in its clinical outcome. Adenosine deaminase (ADA) is a key enzyme in the purine metabolic pathway; it was found to be upregulated in PCa and is associated with higher-grade PCa and poor disease-free survival. The inosine-to-adenosine ratio, which is a surrogate for ADA activity was high in PCa patient urine and higher in AA PCa compared to EA PCa. To understand the significance of high ADA in PCa, we established ADA overexpression models and performed various
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