The Tumor-Immune Ecosystem in Shaping Metastasis

Authors

Yang Gao
Jeffrey M Rosen
Xiang H-F Zhang

Language

English

Publication Date

3-1-2023

Journal

American Journal of Physiology-Cell Physiology

DOI

10.1152/ajpcell.00132.2022

PMID

36717100

PMCID

PMC10027084

PubMedCentral® Posted Date

1-30-2023

PubMedCentral® Full Text Version

Post-Print

Abstract

A better understanding of the mechanisms regulating cancer metastasis is critical to develop new therapies and decrease mortality. Emerging evidence suggests that the interactions between tumor cells and the host immune system play important roles in establishing metastasis. Tumor cells are able to recruit immune cells, which in turn promotes tumor cell invasion, intravasation, survival in circulation, extravasation, and colonization in different organs. The tumor-host immunological interactions also generate a premetastatic niche in distant organs which facilitates metastasis. In this review, we summarize the recent findings on how tumor cells and immune cells regulate each other to coevolve and promote the formation of metastases at the major organ sites of metastasis.

Keywords

Humans, Ecosystem, Neoplasms, Neoplastic Stem Cells, Neoplasm Metastasis, Tumor Microenvironment, ecosystem, immune, metastasis, organotropism, tumor

Published Open-Access

yes

Recommended Citation

Yang Gao, Jeffrey M Rosen, and Xiang H-F Zhang, "The Tumor-Immune Ecosystem in Shaping Metastasis" (2023). Faculty and Staff Publications. 2063.
https://digitalcommons.library.tmc.edu/baylor_docs/2063