Publication Date
3-1-2023
Journal
American Journal of Physiology-Cell Physiology
DOI
10.1152/ajpcell.00132.2022
PMID
36717100
PMCID
PMC10027084
PubMedCentral® Posted Date
1-30-2023
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Humans, Ecosystem, Neoplasms, Neoplastic Stem Cells, Neoplasm Metastasis, Tumor Microenvironment, ecosystem, immune, metastasis, organotropism, tumor
Abstract
A better understanding of the mechanisms regulating cancer metastasis is critical to develop new therapies and decrease mortality. Emerging evidence suggests that the interactions between tumor cells and the host immune system play important roles in establishing metastasis. Tumor cells are able to recruit immune cells, which in turn promotes tumor cell invasion, intravasation, survival in circulation, extravasation, and colonization in different organs. The tumor-host immunological interactions also generate a premetastatic niche in distant organs which facilitates metastasis. In this review, we summarize the recent findings on how tumor cells and immune cells regulate each other to coevolve and promote the formation of metastases at the major organ sites of metastasis.
Graphical Abstract
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Biological Phenomena, Cell Phenomena, and Immunity Commons, Life Sciences Commons, Medical Cell Biology Commons, Medical Microbiology Commons, Medical Molecular Biology Commons, Oncology Commons