Language
English
Publication Date
9-1-2024
Journal
Advanced Science
DOI
10.1002/advs.202310037
PMID
38953362
PMCID
PMC11434141
PubMedCentral® Posted Date
7-2-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Programmed death-ligand 1 (PD-L1) is overexpressed in multiple cancers and critical for their immune escape. It has previously shown that the nuclear coactivator SRC-1 promoted colorectal cancer (CRC) progression by enhancing CRC cell viability, yet its role in CRC immune escape is unclear. Here, we demonstrate that SRC-1 is positively correlated with PD-L1 in human CRC specimens. SRC-1 deficiency significantly inhibits PD-L1 expression in CRC cells and retards murine CRC growth in subcutaneous grafts by enhancing CRC immune escape via increasing tumor infiltration of CD8
Keywords
Colorectal Neoplasms, Animals, Mice, B7-H1 Antigen, Humans, Nuclear Receptor Coactivator 1, Tumor Escape, Disease Models, Animal, Protein Stability, Cell Line, Tumor, Mice, Inbred C57BL
Published Open-Access
yes
Recommended Citation
Hong, Yilin; Chen, Qiang; Wang, Zinan; et al., "Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1" (2024). Faculty and Staff Publications. 2076.
https://digitalcommons.library.tmc.edu/baylor_docs/2076
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Life Sciences Commons, Medical Cell Biology Commons, Medical Genetics Commons, Medical Microbiology Commons, Medical Molecular Biology Commons, Oncology Commons