Loss of the Endoplasmic Reticulum Protein Tmem208 Affects Cell Polarity, Development, and Viability

Authors

Debdeep Dutta
Oguz Kanca
Rishi V Shridharan
Paul C Marcogliese
Benjamin Steger
Marie Morimoto
F Graeme Frost
Ellen Macnamara
Michael F Wangler
Shinya Yamamoto
Andreas Jenny
David Adams
May C Malicdan
Hugo J Bellen

Publication Date

2-27-2024

Journal

Proceedings of the National Academy of Sciences of the United States of America

DOI

10.1073/pnas.2322582121

PMID

38381787

PMCID

PMC10907268

PubMedCentral® Posted Date

2-21-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, Child, Animals, Mice, Drosophila Proteins, Cell Polarity, Drosophila, Signal Transduction, Endoplasmic Reticulum, Membrane Proteins, TMEM proteins, hSnd2, PCP, ER stress, Drosophila

Abstract

Nascent proteins destined for the cell membrane and the secretory pathway are targeted to the endoplasmic reticulum (ER) either posttranslationally or cotranslationally. The signal-independent pathway, containing the protein TMEM208, is one of three pathways that facilitates the translocation of nascent proteins into the ER. The in vivo function of this protein is ill characterized in multicellular organisms. Here, we generated a CRISPR-induced null allele of the fruit fly ortholog

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