Publication Date
10-1-2023
Journal
Trend in Genetics
DOI
10.1016/j.tig.2023.06.006
PMID
37419698
PMCID
PMC10527280
PubMedCentral® Posted Date
10-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Animals, Chromatin, Aging, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Mammals, Transcription, Genetic, Cryptic transcription, aging, chromatin
Abstract
The mechanisms that underlie increased cryptic transcription during senescence and aging have been poorly understood. Sen et al. recently identified cryptic transcription start sites (cTSSs) and chromatin state changes that may contribute to cTSS activation in mammals. Their results indicate that enhancer-promoter conversion may drive cryptic transcription in senescence.
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