Language

English

Publication Date

7-1-2024

Journal

Nature Aging

DOI

10.1038/s43587-024-00631-1

PMID

38816550

PMCID

PMC11257944

PubMedCentral® Posted Date

5-30-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes differ among various tissues and how those lifespan-extending strategies slow tissue aging in distinct manners remain unclear. Here we generated the transcriptomic Cell Atlas of Worm Aging (CAWA, http://mengwanglab.org/atlas ) of wild-type and long-lived strains. We discovered cell-specific, age-related molecular and functional signatures across all somatic and germ cell types. We developed transcriptomic aging clocks for different tissues and quantitatively determined how three different pro-longevity strategies slow tissue aging distinctively. Furthermore, through genome-wide profiling of alternative polyadenylation (APA) events in different tissues, we discovered cell-type-specific APA changes during aging and revealed how these changes are differentially affected by the pro-longevity strategies. Together, this study offers fundamental molecular insights into both somatic and reproductive aging and provides a valuable resource for in-depth understanding of the diversity of pro-longevity mechanisms.

Keywords

Longevity, Animals, Aging, Transcriptome, Caenorhabditis elegans, Polyadenylation, Organ Specificity, Gene Expression Profiling, Germ Cells, Ageing, RNA sequencing

Published Open-Access

yes

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