Publication Date
10-1-2023
Journal
Food Science & Nutrition
DOI
10.1002/fsn3.3616
PMID
37823158
PMCID
PMC10563750
PubMedCentral® Posted Date
8-9-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
no
Keywords
cardiac function biomarkers, cardiotoxicity, cranberry, metaproterenol
Abstract
Cranberry offers numerous cardiovascular benefits. According to several studies, this fruit promotes the oxidation of low‐density lipoprotein, enhances high‐density lipoprotein, reduces platelet coagulation, and improves vascular activity. Albino male rats were divided into five groups (n = 5 per group). The control group received intraperitoneal administration of normal saline. The second group was injected with metaproterenol (MET) 3 days a week for 4 weeks. The third, fourth, and fifth groups were given cranberry extract in doses of 75, 100, and 150, respectively, along with heart‐damaging drugs. Blood samples were collected and sent to the laboratory on the fourth weekend and 1 week after completing the injections in the fourth week (the sixth weekend) for analyzing serum factors such as cardiac creatine kinase MB, cardiac troponin I (cTnI), and aspartate aminotransferase (AST). The serum activity of the cardiac evaluation parameters in the fourth week demonstrated a highly significant correlation among the groups with respect to AST and cTnI (p < .001). Additionally, a significant relationship was observed between AST and cTnI within the target groups (p < .05). Ultimately, the findings indicated that the consumption of cranberry extract, due to its impact on heart function, could effectively modify serum indicators associated with heart damage. The utilized extract also exhibited efficacy, albeit with variable effects. Therefore, it is recommended to use cranberry extract synergistically with other chemical and herbal medications to achieve more sustained effects.
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Biological Phenomena, Cell Phenomena, and Immunity Commons, Cardiology Commons, Cardiovascular Diseases Commons, Dietetics and Clinical Nutrition Commons, Food Science Commons, Medical Biochemistry Commons
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