Publication Date
4-29-2024
Journal
Sensors
DOI
10.3390/s24092823
PMID
38732929
PMCID
PMC11086151
PubMedCentral® Posted Date
4-29-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Electroencephalography, Machine Learning, Seizures, Epilepsy, Neural Networks, Computer, Adult, Male, Algorithms, Female, Middle Aged, convolutional neural network, image recognition, epilepsy, electroencephalograms
Abstract
The treatment of epilepsy, the second most common chronic neurological disorder, is often complicated by the failure of patients to respond to medication. Treatment failure with anti-seizure medications is often due to the presence of non-epileptic seizures. Distinguishing non-epileptic from epileptic seizures requires an expensive and time-consuming analysis of electroencephalograms (EEGs) recorded in an epilepsy monitoring unit. Machine learning algorithms have been used to detect seizures from EEG, typically using EEG waveform analysis. We employed an alternative approach, using a convolutional neural network (CNN) with transfer learning using MobileNetV2 to emulate the real-world visual analysis of EEG images by epileptologists. A total of 5359 EEG waveform plot images from 107 adult subjects across two epilepsy monitoring units in separate medical facilities were divided into epileptic and non-epileptic groups for training and cross-validation of the CNN. The model achieved an accuracy of 86.9% (Area Under the Curve, AUC 0.92) at the site where training data were extracted and an accuracy of 87.3% (AUC 0.94) at the other site whose data were only used for validation. This investigation demonstrates the high accuracy achievable with CNN analysis of EEG plot images and the robustness of this approach across EEG visualization software, laying the groundwork for further subclassification of seizures using similar approaches in a clinical setting.
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