Improving Outcomes for Infants After Cardiopulmonary Bypass Surgery for Congenital Heart Disease: A Commentary on Recent Randomized Controlled Trials

Authors

Luregn J Schlapbach
Kristen S Gibbons
Warwick Butt
Prince J Kannankeril
Jennifer S Li
Kevin D Hill

Publication Date

11-1-2023

Journal

Pediatric Critical Care Medicine

DOI

10.1097/PCC.0000000000003344

PMID

37607086

PMCID

PMC10840795

PubMedCentral® Posted Date

11-1-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Humans, Infant, Cardiopulmonary Bypass, Randomized Controlled Trials as Topic, Heart Defects, Congenital, Cardiac Surgical Procedures, cardiopulmonary bypass, congenital heart disease, critical care, infant, surgery, trial

Abstract

The recent NITRIC and STRESS trials demonstrate opportunities to perform pragmatic large randomized trials in congenital heart disease. We discuss lessons learnt from these trials which can inform future trial design and conduct in the field of pediatric heart surgery.