Publication Date
9-1-2023
Journal
Movement Disorders Clinical Practice
DOI
10.1002/mdc3.13827
PMID
37772296
PMCID
PMC10525044
PubMedCentral® Posted Date
8-3-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
dystonia, cervical dystonia, torticollis, depression, anxiety, patient‐reported outcome measure, rating scale
Abstract
BACKGROUND: Assessing disease severity can be performed using either clinician-rated scales (CRS) or patient-rated outcome (PRO) tools. These two measures frequently demonstrate poor correlations.
OBJECTIVES: To determine if the correlation between a CRS and PRO for motor features of cervical dystonia (CD) improves by accounting for non-motor features.
METHODS: Subjects with CD (N = 209) were evaluated using a CRS (Toronto Western Spasmodic Torticollis Rating Scale, TWSTRS) and a PRO (Cervical Dystonia Impact Profile, CDIP-58).
RESULTS: Linear regression revealed a weak correlation between the two measures, even when considering only the motor subscales of each. The strength of this relationship improved with a regression model that included non-motor symptoms of pain, depression, and disability.
CONCLUSIONS: These results argue that the results of motor assessments in a PRO for CD cannot be fully appreciated without simultaneous assessment of non-motor co-morbidities. This conclusion might apply to other disorders, especially those with frequent non-motor co-morbidities.
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