Publication Date
2-1-2024
Journal
Alzheimer's & Dementia Journal
DOI
10.1002/alz.13365
PMID
37776210
PMCID
PMC10916955
PubMedCentral® Posted Date
2-20-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Aged, Cognitive Dysfunction, Life Style, Cognition, Exercise, Brain, aging, Alzheimer's disease, clinical trial, cognition, cognitive training, diet, exercise, lifestyle intervention, non‐pharmacological, prevention, risk modification
Abstract
INTRODUCTION: The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans.
METHODS: U.S. POINTER was planned as a 2-year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well-established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER.
RESULTS: U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cognitive/social stimulation, and cardiovascular health, but differ in intensity and accountability. The study partners with a worldwide network of similar trials for harmonization of methods and data sharing.
DISCUSSION: U.S. POINTER is testing a potentially sustainable intervention to support brain health and Alzheimer's prevention for Americans. Impact is strengthened by the targeted participant diversity and expanded scientific scope through ancillary studies.
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Cognition and Perception Commons, Medical Sciences Commons, Mental and Social Health Commons, Neurology Commons