Publication Date
7-21-2023
Journal
iScience
DOI
10.1016/j.isci.2023.106931
PMID
37534172
PMCID
PMC10391582
PubMedCentral® Posted Date
5-29-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Cognitive neuroscience, Molecular neuroscience, Neuroscience
Abstract
Neuronal impairment is a characteristic of Alzheimer's disease (AD), but its effect on neural activity dynamics underlying memory deficits is unclear. Here, we studied the effects of synaptic impairment on neural activities associated with memory recall, memory rescue, and learning a new memory, in an integrate-and-fire neuronal network. Our results showed that reducing connectivity decreases the neuronal synchronization of memory neurons and impairs memory recall performance. Although, slow-gamma stimulation rescued memory recall and slow-gamma oscillations, the rescue caused a side effect of activating mixed memories. During the learning of a new memory, reducing connectivity caused impairment in storing the new memory, but did not affect previously stored memories. We also explored the effects of other types of impairments including neuronal loss and excitation-inhibition imbalance and the rescue by general increase of excitability. Our results reveal potential computational mechanisms underlying the memory deficits caused by impairment in AD.
Graphical Abstract