Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression
Publication Date
12-1-2024
Journal
Cancer Research Communications
DOI
10.1158/2767-9764.CRC-24-0281
PMID
39601621
PMCID
PMC11683667
PubMedCentral® Posted Date
12-30-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Glioma, Animals, Mice, Membrane Glycoproteins, CD83 Antigen, Antigens, CD, Immunoglobulins, Brain Neoplasms, Disease Progression, Cell Line, Tumor, Immune Tolerance, CD8-Positive T-Lymphocytes, Cytokines, Immunosuppression Therapy
Abstract
Immunosuppression in malignant glioma remains a barrier to therapeutic development. CD83 overexpression in human and mouse glioma increases survival. CD83+ tumor cells promote signatures related to cytotoxic T cells, enhanced activation of CD8+ T cells, and increased proinflammatory cytokines. These findings suggest that tumor-expressed CD83 could mediate tumor-immune communications.