Publication Date
3-1-2023
Journal
Nature Reviews Neuroscience
DOI
10.1038/s41583-022-00661-x
PMID
36456807
PMCID
PMC10041987
PubMedCentral® Posted Date
3-27-2023
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Animals, Humans, Gyrus Cinguli, Cerebral Cortex, Cognition, Memory, Magnetic Resonance Imaging
Abstract
The posterior cingulate cortex (PCC) is one of the least understood regions of the cerebral cortex. By contrast, the anterior cingulate cortex has been the subject of intensive investigation in humans and model animal systems, leading to detailed behavioural and computational theoretical accounts of its function. The time is right for similar progress to be made in the PCC given its unique anatomical and physiological properties and demonstrably important contributions to higher cognitive functions and brain diseases. Here, we describe recent progress in understanding the PCC, with a focus on convergent findings across species and techniques that lay a foundation for establishing a formal theoretical account of its functions. Based on this converging evidence, we propose that the broader PCC region contains three major subregions - the dorsal PCC, ventral PCC and retrosplenial cortex - that respectively support the integration of executive, mnemonic and spatial processing systems. This tripartite subregional view reconciles inconsistencies in prior unitary theories of PCC function and offers promising new avenues for progress.