Publication Date
11-8-2023
Journal
The Journal of Neuroscience
DOI
10.1523/JNEUROSCI.1427-23.2023
PMID
37940596
PMCID
PMC10634582
PubMedCentral® Posted Date
11-8-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Deep Brain Stimulation, Brain, Electric Stimulation, Magnetic Resonance Imaging, Electrodes, coordinated reset, deep brain stimulation, evoked potentials, functional magnetic resonance imaging, sweet spot mapping
Abstract
Deep brain stimulation (DBS) is an effective therapy for various neurologic and neuropsychiatric disorders, involving chronic implantation of electrodes into target brain regions for electrical stimulation delivery. Despite its safety and efficacy, DBS remains an underutilized therapy. Advances in the field of DBS, including in technology, mechanistic understanding, and applications have the potential to expand access and use of DBS, while also improving clinical outcomes. Developments in DBS technology, such as MRI compatibility and bidirectional DBS systems capable of sensing neural activity while providing therapeutic stimulation, have enabled advances in our understanding of DBS mechanisms and its application. In this review, we summarize recent work exploring DBS modulation of target networks. We also cover current work focusing on improved programming and the development of novel stimulation paradigms that go beyond current standards of DBS, many of which are enabled by sensing-enabled DBS systems and have the potential to expand access to DBS.