Ectopic Lymphoid Structures in the Aged Lacrimal Glands

Authors

Jeremias G Galletti
Kaitlin K Scholand
Claudia M Trujillo-Vargas
Zhiyuan Yu
Olivier Mauduit
Vanessa Delcroix
Helen P Makarenkova
Cintia S de Paiva

Language

English

Publication Date

3-1-2023

Journal

Clinical Immunology

DOI

10.1016/j.clim.2023.109251

PMID

36740002

PMCID

PMC10323865

PubMedCentral® Posted Date

3-1-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates that suggest ectopic lymphoid structures. However, these ectopic lymphoid structures have not been fully investigated. Using C57BL/6J mice of different ages, we analyzed the transcriptome of aged murine LGs and characterized the B and T cell populations. Age-related changes in the LG include increased differentially expressed genes associated with B and T cell activation, germinal center formation, and infiltration by marginal zone-like B cells. We also identified an age-related increase in B1

Keywords

Mice, Animals, Lacrimal Apparatus, Mice, Inbred C57BL, Sjogren's Syndrome, B-Lymphocytes, Lymphoid Tissue

Published Open-Access

yes

Recommended Citation

Galletti, Jeremias G; Scholand, Kaitlin K; Trujillo-Vargas, Claudia M; et al., "Ectopic Lymphoid Structures in the Aged Lacrimal Glands" (2023). Faculty and Staff Publications. 2756.
https://digitalcommons.library.tmc.edu/baylor_docs/2756