Publication Date
3-1-2023
Journal
Clinical Immunology
DOI
10.1016/j.clim.2023.109251
PMID
36740002
PMCID
PMC10323865
PubMedCentral® Posted Date
3-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Mice, Animals, Lacrimal Apparatus, Mice, Inbred C57BL, Sjogren's Syndrome, B-Lymphocytes, Lymphoid Tissue
Abstract
Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates that suggest ectopic lymphoid structures. However, these ectopic lymphoid structures have not been fully investigated. Using C57BL/6J mice of different ages, we analyzed the transcriptome of aged murine LGs and characterized the B and T cell populations. Age-related changes in the LG include increased differentially expressed genes associated with B and T cell activation, germinal center formation, and infiltration by marginal zone-like B cells. We also identified an age-related increase in B1
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