Language
English
Publication Date
1-1-2024
Journal
Pediatric and Developmental Pathology
DOI
10.1177/10935266241230600
PMID
38468555
PMCID
PMC11340240
PubMedCentral® Posted Date
3-11-2024
PubMedCentral® Full Text Version
Post-print
Abstract
We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH. Next generation sequencing revealed deleterious TP53 and MYC mutations. We concluded that both could be diagnosed as “DLBCL-NOS with MYC rearrangement” using the current pathologic classifications, 2022 International Consensus Classification (ICC) and World Health Organization Classifications of Haematolymphoid Tumors (WHO-HAEM5). This report illustrates diagnostic challenges and treatment dilemmas that may be encountered, particularly for adolescent and young adults (AYA).
Keywords
Humans, Burkitt Lymphoma, Lymphoma, Large B-Cell, Diffuse, Proto-Oncogene Proteins c-bcl-2, Adolescent, Male, Translocation, Genetic, Child, Female, Diagnosis, Differential, Biomarkers, Tumor, Chromosomes, Human, Pair 14, Neoplasm Recurrence, Local, Chromosomes, Human, Pair 8, BCL2, Burkitt, DLBCL, aggressive b-cell non-Hodgkin lymphoma, B-NHL, ICC, WHO-HAEM5, pediatric
Published Open-Access
yes
Recommended Citation
El Dana, Fouad; Garces Narvaez, Sofia Alexandra; El-Mallawany, Nader K; et al., "Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge" (2024). Faculty and Staff Publications. 2893.
https://digitalcommons.library.tmc.edu/baylor_docs/2893
Included in
Immunology of Infectious Disease Commons, Immunopathology Commons, Medical Immunology Commons, Oncology Commons, Pathology Commons, Pediatrics Commons