Language
English
Publication Date
2-1-2022
Journal
FASEB BioAdvances
DOI
10.1096/fba.2021-00078
PMID
35141475
PMCID
PMC8814561
PubMedCentral® Posted Date
11-1-2021
PubMedCentral® Full Text Version
Post-print
Abstract
The purpose of our experiment was to explore how stochastic (inter-individual variation) gut microbiome composition may link to inflammatory bowel disease (IBD) susceptibility and guide the development of a perinatal preventative probiotic. Dextran sodium sulfate (DSS) was introduced to C57BL/BJ mice to induce acute colitis as a model of IBD. Potentially protective bacteria were identified using a discovery-validation cohort approach toward stochastic DSS susceptibility.
Keywords
: inflammatory bowel disease, Lactobacillus, microbiota, pediatric, probiotic, stochastic
Published Open-Access
yes
Recommended Citation
Krishna, Mahesh; Engevik, Melinda; Queliza, Karen; et al., "Maternal Lactobacillus reuteri Supplementation Shifts the Intestinal Microbiome in Mice and Provides Protection From Experimental Colitis in Female Offspring" (2022). Faculty and Staff Publications. 2921.
https://digitalcommons.library.tmc.edu/baylor_docs/2921
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Gastroenterology Commons, Immunology of Infectious Disease Commons, Immunopathology Commons, Medical Cell Biology Commons, Medical Immunology Commons, Pathology Commons