Publication Date
7-1-2022
Journal
Leukemia
DOI
10.1038/s41375-022-01613-1
PMID
35732831
PMCID
PMC9252913
PubMedCentral® Posted Date
6-22-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Hematologic Neoplasms, Histiocytosis, Humans, World Health Organization, Haematological cancer, Diagnosis
Abstract
The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.
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Hematology Commons, Medical Sciences Commons, Neoplasms Commons, Oncology Commons, Pediatrics Commons