Language

English

Publication Date

7-1-2024

Journal

Journal of Hepatology

DOI

10.1016/j.jhep.2024.03.031

PMID

38527522

PMCID

PMC11193657

PubMedCentral® Posted Date

7-1-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

Patients with cirrhosis are prone to developing acute kidney injury (AKI), a complication associated with a markedly increased in-hospital morbidity and mortality, along with a risk of progression to chronic kidney disease. Whereas patients with cirrhosis are at increased risk of developing any phenotype of AKI, hepatorenal syndrome (HRS), a specific form of AKI (HRS-AKI) in patients with advanced cirrhosis and ascites, carries an especially high mortality risk. Early recognition of HRS-AKI is crucial since administration of splanchnic vasoconstrictors may reverse the AKI and serve as a bridge to liver transplantation, the only curative option. In 2023, a joint meeting of the International Club of Ascites (ICA) and the Acute Disease Quality Initiative (ADQI) was convened to develop new diagnostic criteria for HRS-AKI, to provide graded recommendations for the work-up, management and post-discharge follow-up of patients with cirrhosis and AKI, and to highlight priorities for further research.

Keywords

Humans, Acute Kidney Injury, Liver Cirrhosis, Hepatorenal Syndrome, Ascites, Consensus

Published Open-Access

yes

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