Language
English
Publication Date
8-19-2024
Journal
BMC Nephrology
DOI
10.1186/s12882-024-03705-9
PMID
39160464
PMCID
PMC11334345
PubMedCentral® Posted Date
8-19-2024
PubMedCentral® Full Text Version
Post-print
Abstract
BACKGROUND: Complications of prolonged continuous kidney replacement therapy (CKRT) have not been well described. Our objective was to describe mineral metabolism and bone findings in children who required prolonged CKRT.
METHODS: In this single center prospective observational study, we enrolled 37 patients who required CKRT for ≥ 28 days with regional citrate anticoagulation. Exposure was duration on CKRT and outcomes were 25-hydroxy vitamin D and osteopenia and/or fractures.
RESULTS: The prevalence of vitamin D deficiency and insufficiency was 17.2% and 69.0%, respectively. 29.7% of patients had radiographic findings of osteopenia and/or fractures. There was no association between vitamin D deficiency or insufficiency with age or ethnicity. Time on CKRT and intact PTH levels were not predictive of vitamin D levels. Children with chronic liver disease were more likely to have osteopenia and/or fractures compared children with other primary diagnoses, odds ratio (3.99 (95%CI, 1.58-2.91), p = 0.003) after adjusting for age and time on CKRT.
CONCLUSION: Vitamin D deficiency and/or insufficiency, and osteopenia and/or fractures are prevalent among children who require CKRT for a prolonged period. The risk for MBD may be higher with chronic liver disease. Higher doses of vitamin D may be required to maintain normal levels while on CKRT.
Keywords
Humans, Female, Male, Bone Diseases, Metabolic, Prospective Studies, Vitamin D Deficiency, Child, Vitamin D, Child, Preschool, Adolescent, Continuous Renal Replacement Therapy, Fractures, Bone, Prevalence
Published Open-Access
yes
Recommended Citation
Imani, Peace Dorothy; Vega, Molly; Pekkucuksen, Naile Tufan; et al., "Vitamin D and Metabolic Bone Disease in Prolonged Continuous Kidney Replacement Therapy: A Prospective Observational Study" (2024). Faculty and Staff Publications. 3019.
https://digitalcommons.library.tmc.edu/baylor_docs/3019