Candidate Biomarkers as Predictors of Future Kidney Disease and Cardiovascular Dysfunction in Adolescents with Type 2 Diabetes

Authors

Fida Bacha
Laure El Ghormli
Barbara H Braffett
Amy S Shah
Santica M Marcovina
Lorraine E Levitt Katz
Steven M Willi
Sonia Caprio
Ruban Dhaliwal
Samuel S Gidding

Language

English

Publication Date

5-1-2023

Journal

Diabetes Research and Clinical Practice

DOI

10.1016/j.diabres.2023.110671

PMID

37068551

PMCID

PMC10207151

PubMedCentral® Posted Date

5-1-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

AIMS: Evaluate changes in circulating biomarkers as predictors of kidney disease, and cardiac/vascular dysfunction in participants from the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study.

METHODS: Candidate biomarkers were assessed annually in 507 participants over a mean follow-up of 6.9 ± 2.4 years. Moderate albuminuria was defined as urine albumin-to-creatinine ratio ≥ 30 mg/g and hyperfiltration as eGFR ≥ 135 mL/min/1.73 m

RESULTS: At baseline, 35.7% were male, with a mean age 13.9 years, diabetes duration 7.8 months, and HbA1c 6.0%. Higher concentrations of E-selectin and proinsulin were associated with incident moderate albuminuria and hyperfiltration. Higher concentrations of FGF-23 were associated with lower risk of hyperfiltration and negatively correlated with eGFR. No candidate biomarkers predicted a decline in cardiac or vascular function.

CONCLUSIONS: Circulating biomarkers of endothelial dysfunction and markers of β-cell dysfunction and insulin sensitivity could be used in a more personalized risk assessment of kidney disease in youth-onset type 2 diabetes. However, biomarkers studied have limited value in predicting cardiac dysfunction or vascular stiffness.

Keywords

Humans, Male, Adolescent, Female, Diabetes Mellitus, Type 2, Albuminuria, Pulse Wave Analysis, Glomerular Filtration Rate, Kidney Diseases, Biomarkers, Risk Factors, type 2 diabetes, pediatrics, circulating biomarkers, kidney disease, cardiovascular disease, risk assessment

Published Open-Access

yes

Recommended Citation

Bacha, Fida; El Ghormli, Laure; Braffett, Barbara H; et al., "Candidate Biomarkers as Predictors of Future Kidney Disease and Cardiovascular Dysfunction in Adolescents with Type 2 Diabetes" (2023). Faculty and Staff Publications. 3091.
https://digitalcommons.library.tmc.edu/baylor_docs/3091