Language
English
Publication Date
1-1-2024
Journal
Hormone Research in Paediatrics
DOI
10.1159/000543035
PMID
39662065
PMCID
PMC11854978
PubMedCentral® Posted Date
12-11-2024
PubMedCentral® Full Text Version
Post-print
Abstract
The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed. The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed.
Keywords
Humans, Diabetes Mellitus, Type 1, Adolescent, Child, Insulin-Secreting Cells, Female, Societies, Medical, Male
Published Open-Access
yes
Recommended Citation
Haller, Michael J; Bell, Kirstine J; Besser, Rachel E J; et al., "ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes" (2024). Faculty and Staff Publications. 3125.
https://digitalcommons.library.tmc.edu/baylor_docs/3125
Included in
Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Internal Medicine Commons, Medical Sciences Commons, Pediatrics Commons