Publication Date
11-1-2023
Journal
Pancreatology
DOI
10.1016/j.pan.2023.08.006
PMID
37723006
PMCID
PMC10843133
PubMedCentral® Posted Date
11-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Humans, Child, Adolescent, Cross-Sectional Studies, Bone Density, Retrospective Studies, Pancreatitis, Chronic
Abstract
BACKGROUND/OBJECTIVES: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied.
METHODS: This retrospective study was performed at three sites and included data from INSPPIRE-2.
RESULTS: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < -2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < -2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively).
CONCLUSION: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.
Included in
Digestive System Diseases Commons, Gastroenterology Commons, Medical Sciences Commons, Pediatrics Commons
