Language
English
Publication Date
5-1-2022
Journal
Neurogastroenterology & Motility
DOI
10.1111/nmo.14270
PMID
34595805
PMCID
PMC8971139
PubMedCentral® Posted Date
5-1-2023
PubMedCentral® Full Text Version
Author MSS
Abstract
BACKGROUND: Autoimmunity may play a role in the pathogenesis of gastroparesis in a subset of patients. Antinuclear antibody (ANA) testing is often used to screen for autoimmune disorders.
AIMS: 1) Determine prevalence of a positive ANA in patients with gastroparesis; 2) Describe characteristics of idiopathic gastroparesis patients with positive ANA.
METHODS: Patients were assessed with gastric emptying scintigraphy (GES), symptom assessment via Patient Assessment of Upper GI Symptoms [PAGI-SYM], and blood tests-ANA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP).
RESULTS: Positive ANA was seen in 148 of 893 (17%) patients with gastroparesis, being similar in idiopathic (16% of 536 patients), T1DM (16% of 162), T2DM (18% of 147), and postfundoplication (19% of 48 patients) gastroparesis. Among 536 patients with idiopathic gastroparesis, ANA titer 1:40-1:80 was seen in 33 (6%) patients, 1:160-1:320 in 36 (7%) patients, and ≥1:640 in 17 (3%) patients. Increasing ANA titer was associated with female gender (p = 0.05), Hispanic ethnicity (p = 0.02), comorbid rheumatoid arthritis (p = 0.02), systemic sclerosis (p = 0.004), and elevated ESR (p = 0.007). ANA positivity was associated with lower total GCSI (p = 0.007) and lower nausea/vomiting subscale (p = 0.0005), but not related to gastric emptying.
CONCLUSIONS: The prevalence of a positive ANA in patients with gastroparesis was high at ~17% and did not differ significantly based on etiology. In idiopathic patients, ANA positivity was associated with rheumatoid arthritis, systemic sclerosis, and elevated ESR. ANA-positive gastroparesis represents a subset who often have other autoimmune symptoms or disorders, but less severe nausea and vomiting.
Keywords
Antibodies, Antinuclear, Arthritis, Rheumatoid, Female, Gastric Emptying, Gastroparesis, Humans, Nausea, Prevalence, Scleroderma, Systemic, Vomiting, autoimmune, idiopathic gastroparesis, gastric emptying
Published Open-Access
yes
Recommended Citation
Parkman, Henry P; Van Natta, Mark L; Makol, Ashima; et al., "Prevalence and Clinical Correlates of Antinuclear Antibody in Patients with Gastroparesis" (2022). Faculty and Staff Publications. 3234.
https://digitalcommons.library.tmc.edu/baylor_docs/3234
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