Publication Date
11-14-2022
Journal
Pathogens
DOI
10.3390/pathogens11111343
PMID
36422596
PMCID
PMC9695813
PubMedCentral® Posted Date
11-14-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
tuberculosis, Mycobacterium tuberculosis, sequencing, high throughput sequencing, next generation sequencing
Abstract
High throughput sequencing (HTS) can identify the presence of Mycobacterium tuberculosis DNA in a clinical sample while also providing information on drug susceptibility. Multiple studies have provided a context for exploring the clinical application of HTS for TB diagnosis. The workflow challenges, strengths and limitations of the various sequencing platforms, and tools used for analysis are presented to provide a framework for further innovations in the field.
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Digestive System Diseases Commons, Gastroenterology Commons, Hepatology Commons, Medical Sciences Commons, Pathological Conditions, Signs and Symptoms Commons
