Publication Date
1-1-2023
Journal
Newborn
DOI
10.5005/jp-journals-11002-0069
PMID
37974929
PMCID
PMC10653206
PubMedCentral® Posted Date
11-15-2023
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Anthropometric, Adhesions, Bell’s criteria, Cholestasis, Farnesoid X, Fenton growth, Fish oil-containing lipid emulsion, Fistula, Ileocecal valve, Intralipids, Infant, Intestinal failure, Liver X receptors, Logistic regression, Necrotizing enterocolitis, Neonate, Outcome, Parenteral nutrition, Perforations, Pneumoperitoneum, Pneumatosis, Portal venous gas, Preterm, Premature, Soybean oil–medium chain triglycerides–olive oil–fish oil, Surgical site infection, Stricture, Term-equivalent age, Weight-for-length, Wound dehiscence, z-scores
Abstract
BACKGROUND: We sought to investigate the clinical determinants and outcomes of cholestasis in preterm infants with surgical necrotizing enterocolitis (sNEC).
METHODS: Retrospective comparison of clinical information in preterm infants who developed cholestasis vs those who did not.
RESULTS: Sixty-two (62/91, 68.1%) infants with NEC developed cholestasis at any time following the onset of illness. Cholestasis was seen more frequently in those who had received ionotropic support at 24 hours following sNEC diagnosis (87.1% vs 58.6%;
CONCLUSION: Cholestasis was seen in 68% of infants following surgical NEC. The most likely contributive factors are intestinal failure and subsequent PN dependence for longer periods. Our data suggest that identification and prevention of risk factors such as sepsis and surgical complications and early feeds following NEC surgery may improve outcomes.
