Publication Date
1-1-2025
Journal
Frontiers in Neuroscience
DOI
10.3389/fnins.2025.1531122
PMID
40018362
PMCID
PMC11865030
PubMedCentral® Posted Date
2-13-2025
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
AAV, snRNAseq, gene therapy, olfaction, olfactory sensory neurons
Abstract
Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor information to the central nervous system. Unlike other sensory inputs, olfactory sensory neurons interface with the external environment and project their axons directly into the central nervous system. The use of adeno-associated viruses to target these neurons has garnered interest for applications in gene therapy, probing olfactory sensory neuron biology, and modeling disease. To date, there is no consensus on the optimal AAV serotype for efficient and selective transduction of olfactory sensory neurons
Included in
Diseases Commons, Neurology Commons, Neurosciences Commons, Pediatrics Commons
