Genome-Wide Association Studies and Fine-Mapping Identify Genomic Loci for N-3 and N-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts

Authors

• Chaojie Yang
• Jenna Veenstra
• Traci M Bartz
• Matthew C Pahl
• Brian Hallmark
• Yii-Der Ida Chen
• Jason Westra
• Lyn M Steffen
• Christopher D Brown
• David Siscovick
• Michael Y Tsai
• Alexis C Wood
• Stephen S Rich
• Caren E Smith
• Timothy D O'Connor
• Dariush Mozaffarian
• Struan F A Grant
• Floyd H Chilton
• Nathan L Tintle
• Rozenn N Lemaitre
• Ani Manichaikul

Language

English

Publication Date

8-16-2023

Journal

Communications Biology

DOI

10.1038/s42003-023-05219-w

PMID

37587153

PMCID

PMC10432561

PubMedCentral® Posted Date

8-16-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P < 5 × 10

Keywords

Humans, Genome-Wide Association Study, Fatty Acids, Omega-6, Black or African American, Genomics, Hispanic or Latino, Bestrophins, Genetic association study, Metabolic disorders

Published Open-Access

yes

Recommended Citation

Yang, Chaojie; Veenstra, Jenna; Bartz, Traci M; et al., "Genome-Wide Association Studies and Fine-Mapping Identify Genomic Loci for N-3 and N-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts" (2023). Faculty, Staff and Students Publications. 3525.
https://digitalcommons.library.tmc.edu/baylor_docs/3525