Publication Date
7-22-2024
Journal
NPJ Vaccines
DOI
10.1038/s41541-024-00924-x
PMID
39034332
PMCID
PMC11271464
PubMedCentral® Posted Date
7-22-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Vaccines, Microbiology
Abstract
The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.
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