A Trivalent Protein-Based Pan-Betacoronavirus Vaccine Elicits Cross-Neutralizing Antibodies Against a Panel of Coronavirus Pseudoviruses

Authors

Syamala Rani Thimmiraju
Rakesh Adhikari
JeAnna R Redd
Maria Jose Villar
Jungsoon Lee
Zhuyun Liu
Yi-Lin Chen
Suman Sharma
Amandeep Kaur
Nestor L Uzcategui
Shannon E Ronca
Wen-Hsiang Chen
Jason T Kimata
Bin Zhan
Ulrich Strych
Maria Elena Bottazzi
Peter J Hotez
Jeroen Pollet

Language

English

Publication Date

7-22-2024

Journal

NPJ Vaccines

DOI

10.1038/s41541-024-00924-x

PMID

39034332

PMCID

PMC11271464

PubMedCentral® Posted Date

7-22-2024

PubMedCentral® Full Text Version

Post-print

Abstract

The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.

Keywords

Vaccines, Microbiology

Published Open-Access

yes

Recommended Citation

Thimmiraju, Syamala Rani; Adhikari, Rakesh; Redd, JeAnna R; et al., "A Trivalent Protein-Based Pan-Betacoronavirus Vaccine Elicits Cross-Neutralizing Antibodies Against a Panel of Coronavirus Pseudoviruses" (2024). Faculty and Staff Publications. 3603.
https://digitalcommons.library.tmc.edu/baylor_docs/3603