Publication Date
4-2-2020
Journal
Cells
DOI
10.3390/cells9040866
PMID
32252387
PMCID
PMC7226789
PubMedCentral® Posted Date
4-2-2020
PubMedCentral® Full Text Version
Post-print
Published Open-Access
no
Keywords
Humans, Phosphatidylinositols, Phosphorylation, Protein Transport, Retina, Retinal Diseases, Signal Transduction, phosphoinositides, retinal lipids, membrane trafficking
Abstract
Phosphatidylinositol and its phosphorylated derivatives, the phosphoinositides, play many important roles in all eukaryotic cells. These include modulation of physical properties of membranes, activation or inhibition of membrane-associated proteins, recruitment of peripheral membrane proteins that act as effectors, and control of membrane trafficking. They also serve as precursors for important second messengers, inositol (1,4,5) trisphosphate and diacylglycerol. Animal models and human diseases involving defects in phosphoinositide regulatory pathways have revealed their importance for function in the mammalian retina and retinal pigmented epithelium. New technologies for localizing, measuring and genetically manipulating them are revealing new information about their importance for the function and health of the vertebrate retina.
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Biology Commons, Medical Sciences Commons, Medical Specialties Commons