Green Synthesis of Zinc Oxide Nanoparticles from Althaea officinalis Flower Extract Coated with Chitosan for Potential Healing Effects on Diabetic Wounds by Inhibiting TNF-α and IL-6/IL-1β Signaling Pathways

Authors

Sammar Fathy Elhabal
Nashwa Abdelaal
Saeed Abdul Kareem Saeed Al-Zuhairy
Mohamed Fathi Mohamed Elrefai
Ahmed Mohsen Elsaid Hamdan
Mohamed Mansour Khalifa
Sandra Hababeh
Mohammad Ahmad Khasawneh
Gehad M Khamis
Jakline Nelson
Passant M Mohie
Rania A Gad
Amira Rizk
Soad L Kabil
Mohamed Kandeel El-Ashery
Bhaskara R Jasti
Nahla A Elzohairy
Tayseer Elnawawy
Fatma E Hassan
Mohamed A El-Nabarawi

Language

English

Publication Date

1-1-2024

Journal

International Journal of Nanomedicine

DOI

10.2147/IJN.S455270

PMID

38559447

PMCID

PMC10981898

PubMedCentral® Posted Date

3-27-2024

PubMedCentral® Full Text Version

Post-print

Abstract

BACKGROUND: Diabetes Mellitus is a multisystem chronic pandemic, wound inflammation, and healing are still major issues for diabetic patients who may suffer from ulcers, gangrene, and other wounds from uncontrolled chronic hyperglycemia.

METHOD AND RESULTS: First, develop eco-friendly green Zinc Oxide Nanoparticles (ZnO-NPs) and incorporate them into a 2% chitosan (CS) gel. In-vitro study performed by UV-visible spectrum analysis showed a sharp peak at 390 nm, and Energy-dispersive X-ray (EDX) spectrometry showed a peak of zinc and oxygen. Besides, Fourier transforms infrared (FTIR) was used to qualitatively validate biosynthesized ZnO-NPs, and transmission electron microscope (TEM) showed spherical nanoparticles with mean sizes of 76 nm and Zeta potential +30mV. The antibacterial potential of A.O.-ZnO-NPs-Cs was examined by the diffusion agar method against Gram-positive (

CONCLUSION: These biocompatible green zinc oxide nanoparticles, by using

Keywords

Humans, Animals, Rats, Zinc Oxide, Chitosan, Althaea, Interleukin-6, Tumor Necrosis Factor-alpha, Metal Nanoparticles, Anti-Bacterial Agents, Diabetes Mellitus, Wound Healing, Anti-Inflammatory Agents, Inflammation, Flowers, Microbial Sensitivity Tests, Plant Extracts, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction, wound healing, antimicrobial, antioxidant, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, chitosan, wound concentration, wound incision

Published Open-Access

yes

Recommended Citation

Elhabal, Sammar Fathy; Abdelaal, Nashwa; Saeed Al-Zuhairy, Saeed Abdul Kareem; et al., "Green Synthesis of Zinc Oxide Nanoparticles from Althaea officinalis Flower Extract Coated with Chitosan for Potential Healing Effects on Diabetic Wounds by Inhibiting TNF-α and IL-6/IL-1β Signaling Pathways" (2024). Faculty and Staff Publications. 3757.
https://digitalcommons.library.tmc.edu/baylor_docs/3757