Language
English
Publication Date
8-1-2025
Journal
International Journal of Impotence Research
DOI
10.1038/s41443-024-00921-7
PMID
38839905
PMCID
PMC12367543
PubMedCentral® Posted Date
6-5-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Hypogonadism is understudied in men requiring solid organ transplants, particularly among lung transplant recipients. Improvement in serum testosterone levels has been reported in kidney and liver transplantation. Using the TriNetX Research Network, we performed a retrospective cohort study to evaluate the incidence of peri-transplant hypogonadism and the natural course of serum testosterone following successful lung transplantation. Men aged ≥ 18 with a lung transplant and total testosterone drawn within one year pre- and post-transplant were included. Men with receipt of testosterone therapy were excluded. A low testosterone (< 300 ng/dL) and normal testosterone (≥300 ng/dL) cohort was created before employing descriptive and analytic statistics to investigate the incidence of peri-transplant hypogonadism and the change in serum testosterone levels following lung transplantation. In our entire cohort, lung transplantation was not associated with a significant increase in post-transplant serum testosterone (329.86 ± 162.56 ng/dL pre-transplant and 355.13 ± 216.11 ng/dL post-transplant, p = 0.483). The number of men with low testosterone decreased by 9.8% following lung transplantation but was not significant, p = 0.404. In this pilot study, no significant change in the number of hypogonadal men nor serum testosterone levels was observed among men undergoing lung transplantation.
Keywords
Humans, Male, Lung Transplantation, Testosterone, Pilot Projects, Hypogonadism, Middle Aged, Retrospective Studies, Adult, Gonadal disorders, Urogenital diseases
Published Open-Access
yes
Recommended Citation
Thompson, Austin; Omil-Lima, Danly; Perez, Jaime Abraham; et al., "Changes in Post-Transplant Serum Testosterone Levels in Men Undergoing Lung Transplantation: A Pilot Study Using the TriNetX Research Network" (2025). Faculty, Staff and Students Publications. 3792.
https://digitalcommons.library.tmc.edu/baylor_docs/3792