Language
English
Publication Date
6-1-2025
Journal
Nature Reviews Microbiology
DOI
10.1038/s41579-024-01144-9
PMID
39824927
PMCID
PMC12088900
PubMedCentral® Posted Date
6-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide in all age groups and cause significant disease and economic burden globally. To date, no approved vaccines or antiviral therapies are available to treat or prevent HuNoV illness. Several candidate vaccines are in clinical trials, although potential barriers to successful development must be overcome. Recently, significant advances have been made in understanding HuNoV biology owing to breakthroughs in virus cultivation using human intestinal tissue-derived organoid (or enteroid) cultures, advances in structural biology technology combined with epitope mapping and increased metagenomic sequencing. New and unexpected strain-specific differences in pandemic versus non-pandemic virus structures, replication properties and virus-host interactions, including host factors required for susceptibility to infection and pathogenesis, are discussed.
Keywords
Humans, Norovirus, Virus Replication, Caliciviridae Infections, Viral Vaccines, Gastroenteritis, Host-Pathogen Interactions, Vaccine Development
Published Open-Access
yes
Recommended Citation
Prasad, B V Venkataram; Atmar, Robert L; Ramani, Sasirekha; et al., "Norovirus Replication, Host Interactions and Vaccine Advances" (2025). Faculty and Staff Publications. 3863.
https://digitalcommons.library.tmc.edu/baylor_docs/3863