Language
English
Publication Date
8-20-2024
Journal
Nutrients
DOI
10.3390/nu16162767
PMID
39203905
PMCID
PMC11356906
PubMedCentral® Posted Date
8-20-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Caffeine’s metabolism is determined by CYP1A2 genotypes: AC/CC (SLOW) and AA (FAST). This trial evaluated CYP1A2 genotypes’ impact on exercise and cognitive effects in 36 resistance-trained females assessed under placebo (PL) and caffeine (6 mg/kg bw anhydrous caffeine-CAF) conditions, before ingestion and throughout the session. 23andMe® (San Francisco, CA, USA) determined genotypes using saliva. Data were analyzed using two-way RMANOVA and paired-samples t-tests (p < 0.05). A significant main effect for genotype existed for leg press repetitions to failure (RTF) for CAF (p = 0.038), with the FAST group performing more repetitions than the SLOW (p = 0.027). There was a significant condition x genotype interaction for the subjective outcome index score (p = 0.045), with significant differences for time (p < 0.01) and between genotype (p < 0.001). Follow-up analysis revealed a higher total score (p = 0.028) following CAF for the FAST group and a lower total score (p < 0.01) in the SLOW group. Dizziness was reported following CAF in the SLOW group (p = 0.014; Cohen’s d = 0.725). Aside from leg press RTF, subjective outcome index score, and dizziness, the genotype groups experienced similar responses to resistance exercise performance and subjective mood states following caffeine ingestion.
Keywords
Humans, Caffeine, Female, Cytochrome P-450 CYP1A2, Resistance Training, Affect, Genotype, Young Adult, Adult, Performance-Enhancing Substances, Double-Blind Method, caffeine, CYP1A2, resistance training, females
Published Open-Access
yes
Recommended Citation
Prather, Jessica M; Florez, Christine M; Vargas, Amie; et al., "Impact of CYP1A2 Genotypes on the Ergogenic Effects and Subjective Mood States of Caffeine Ingestion in Resistance-Trained Women" (2024). Faculty and Staff Publications. 3967.
https://digitalcommons.library.tmc.edu/baylor_docs/3967