Language
English
Publication Date
1-1-2023
Journal
Archives of Toxicology
DOI
10.1007/s00204-022-03385-0
PMID
36214829
PMCID
PMC10122835
PubMedCentral® Posted Date
4-23-2023
PubMedCentral® Full Text Version
Author MSS
Abstract
Calcium (Ca2+) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+-handling proteins is required for healthy cardiac function, whereas disruption in any of these can cause cardiac arrhythmias. This comprehensive review provides a broad overview of the roles of Ca2+-handling proteins and their regulators in healthy cardiac function and the mechanisms by which mutations in these proteins contribute to inherited arrhythmias. Major Ca2+ channels and Ca2+-sensitive regulatory proteins involved in cardiac excitation–contraction coupling are discussed, with special emphasis on the function of the RyR2 macromolecular complex. Inherited arrhythmia disorders including catecholaminergic polymorphic ventricular tachycardia, long QT syndrome, Brugada syndrome, short QT syndrome, and arrhythmogenic right-ventricular cardiomyopathy are discussed with particular emphasis on subtypes caused by mutations in Ca2+-handling proteins.
Keywords
Humans, Arrhythmias, Cardiac, Myocytes, Cardiac, Tachycardia, Ventricular, Mutation, Calcium Signaling, Calcium, Ryanodine Receptor Calcium Release Channel, Arrhythmia, Calcium, Catecholaminergic polymorphic ventricular tachycardia, Excitation–contraction coupling, Ryanodine receptor
Published Open-Access
yes
Recommended Citation
Keefe, Joshua A; Moore, Oliver M; Ho, Kevin S; et al., "Role of Ca2+ in Healthy and Pathologic Cardiac Function: From Normal Excitation–Contraction Coupling to Mutations That Cause Inherited Arrhythmia" (2023). Faculty and Staff Publications. 4018.
https://digitalcommons.library.tmc.edu/baylor_docs/4018