Language
English
Publication Date
12-1-2024
Journal
The Journal of Cardiovascular Aging
DOI
10.20517/jca.2024.12
PMID
40799849
PMCID
PMC12341829
PubMedCentral® Posted Date
8-12-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart contribute to an increased AF susceptibility. This work critically reviews the key molecular mechanisms that may underpin the complex association between aging and AF. Moreover, we identify emerging novel opportunities for therapeutic intervention that may be able to prevent and/or improve the current treatment paradigms for age-related AF. This review contributes to a holistic understanding of the intricate relationship between aging and AF.
Keywords
Atrial fibrillation, arrhythmia, aging, myocardial remodeling, ryanodine receptor, therapeutic targets
Published Open-Access
yes
Recommended Citation
Zhao, Shuai; Johnston, Aaron M; Yiu, Chi Him Kendrick; et al., "Aging-Associated Mechanisms of Atrial Fibrillation Progression and Their Therapeutic Potential" (2024). Faculty and Staff Publications. 4024.
https://digitalcommons.library.tmc.edu/baylor_docs/4024
Graphical Abstract