Language
English
Publication Date
4-10-2024
Journal
Cancer Letters
DOI
10.1016/j.canlet.2024.216704
PMID
38360138
PMCID
PMC11257378
PubMedCentral® Posted Date
4-10-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Despite significant advancements in prevention and treatment, colorectal cancer (CRC) remains the third leading cause of cancer-related deaths. Animal models, including xenografts, syngeneic, and genetically engineered, have emerged as indispensable tools in cancer research. These models offer a valuable platform to address critical questions regarding molecular pathogenesis and test therapeutic interventions before moving on to clinical trials. Advancements in CRC animal models have also facilitated the advent of personalized and precision medicine. Patient-derived xenografts and genetically engineered mice that mirror features of human tumors allow for tailoring treatments to specific CRC subtypes, improving treatment outcomes and quality of life. To overcome the limitations of individual model systems, recent studies have employed a multi-modal approach, combining different animal models, 3D organoids, and in vitro studies. This integrative approach provides a comprehensive understanding of CRC biology, including the tumor microenvironment and therapeutic responses, driving the development of more effective and personalized therapeutic interventions. This review discusses the animal models used for CRC research, including recent advancements and limitations of these animal models.
Keywords
Mice, Humans, Animals, Colorectal Neoplasms, Quality of Life, Disease Models, Animal, Tumor Microenvironment
Published Open-Access
yes
Recommended Citation
Pothuraju, Ramesh; Khan, Imran; Jain, Maneesh; et al., "Colorectal Cancer Murine Models: Initiation to Metastasis" (2024). Faculty and Staff Publications. 4038.
https://digitalcommons.library.tmc.edu/baylor_docs/4038