Language
English
Publication Date
10-6-2022
Journal
Clinical Chemistry
DOI
10.1093/clinchem/hvac117
PMID
35904048
PMCID
PMC9766881
PubMedCentral® Posted Date
12-20-2022
PubMedCentral® Full Text Version
Author MSS
Abstract
Background: Diabetes exerts adverse effects on the heart, and a longer diabetes duration is associated with greater heart failure risk. We studied diabetes duration and subclinical myocardial injury, as reflected by high-sensitivity cardiac troponin (hs-cTnT).
Methods: We analyzed 9052 participants without heart failure or coronary heart disease (mean age 63 years, 58% female, 21% Black, 15% with diabetes) at The Atherosclerosis Risk in Communities Study (ARIC) Visit 4 (1996 to 1998). Diabetes duration was calculated based on diabetes status at Visits 1 (1987 to 1989) through 4, or using self-reported age of diabetes diagnosis prior to Visit 1. We used multinomial logistic regression to determine the association of diabetes duration with increased (≥14 ng/L) or detectable (≥6 ng/L) Visit 4 hs-cTnT, relative to undetectable hs-cTnT, adjusted for demographics and cardiovascular risk factors.
Results: The prevalence of increased Visit 4 hs-cTnT was higher in persons with longer diabetes duration, from 12% for those with diabetes 0 to < 5 years up to 31% among those with diabetes for ≥15 years (P for trend < 0.0001). New onset diabetes at Visit 4 was associated with 1.92× higher relative risk (95% CI, 1.27-2.91) of increased hs-cTnT than no diabetes. Longer diabetes duration was associated with greater myocardial injury, with duration ≥15 years associated with 9.29× higher risk (95% CI, 5.65-15.29) for increased hs-cTnT and 2.07× (95% CI, 1.24-3.16) for detectable hs-cTnT, compared to no diabetes.
Conclusions: Longer diabetes duration is strongly associated with subclinical myocardial injury. Interventional studies are needed to assess whether the prevention and delay of diabetes onset can mitigate early myocardial damage.
Keywords
Atherosclerosis, Biomarkers, Diabetes Mellitus, Female, Heart Failure, Humans, Male, Middle Aged, Risk Factors, Troponin T
Published Open-Access
yes
Recommended Citation
Hamo, Carine E; Echouffo-Tcheugui, Justin B; Zhang, Sui; et al., "Diabetes Duration and Subclinical Myocardial Injury: The Atherosclerosis Risk in Communities Study (ARIC)" (2022). Faculty and Staff Publications. 4144.
https://digitalcommons.library.tmc.edu/baylor_docs/4144